Immunostimulatory Tim-1–specific antibody deprograms Tregs and prevents transplant tolerance in mice

T cell Ig mucin (Tim) molecules modulate CD4(+) T cell responses. In keeping with the view that Tim-1 generates a stimulatory signal for CD4(+) T cell activation, we hypothesized that an agonist Tim-1–specific mAb would intensify the CD4(+) T cell–dependant allograft response. Unexpectedly, we deter...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Degauque, Nicolas, Mariat, Christophe, Kenny, James, Zhang, Dong, Gao, Wenda, Vu, Minh Diem, Alexopoulos, Sophoclis, Oukka, Mohammed, Umetsu, Dale T., DeKruyff, Rosemarie H., Kuchroo, Vijay, Zheng, Xin Xiao, Strom, Terry B.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2008
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2129234/
https://ncbi.nlm.nih.gov/pubmed/18079964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32562
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker