Allograft rejection is restrained by short-lived TIM-3(+)PD-1(+)Foxp3(+) Tregs

Tregs play a pivotal role in inducing and maintaining donor-specific transplant tolerance. The T cell immunoglobulin and mucin domain-3 protein (TIM-3) is expressed on many fully activated effector T cells. Along with program death 1 (PD-1), TIM-3 is used as a marker for exhausted effector T cells,...

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Detalhes bibliográficos
Main Authors: Gupta, Shipra, Thornley, Thomas B., Gao, Wenda, Larocca, Rafael, Turka, Laurence A., Kuchroo, Vijay K., Strom, Terry B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3386804/
https://ncbi.nlm.nih.gov/pubmed/22684103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI45138
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