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Tim-1 stimulation of dendritic cells regulates the balance between effector and regulatory T cells

We show that Tim-1, initially reported to be expressed on CD4(+) T cells, is constitutively expressed on dendritic cells (DC) and that its expression further increases after DC maturation. Tim-1 signaling into DC upregulates costimulatory molecule expression and proinflammatory cytokine production,...

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Detalhes bibliográficos
Main Authors: Xiao, Sheng, Zhu, Bing, Jin, Hulin, Zhu, Chen, Umetsu, Dale T., DeKruyff, Rosemarie H., Kuchroo, Vijay K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129006/
https://ncbi.nlm.nih.gov/pubmed/21469101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201040993
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