Immunostimulatory Tim-1–specific antibody deprograms Tregs and prevents transplant tolerance in mice

T cell Ig mucin (Tim) molecules modulate CD4(+) T cell responses. In keeping with the view that Tim-1 generates a stimulatory signal for CD4(+) T cell activation, we hypothesized that an agonist Tim-1–specific mAb would intensify the CD4(+) T cell–dependant allograft response. Unexpectedly, we deter...

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Autors principals: Degauque, Nicolas, Mariat, Christophe, Kenny, James, Zhang, Dong, Gao, Wenda, Vu, Minh Diem, Alexopoulos, Sophoclis, Oukka, Mohammed, Umetsu, Dale T., DeKruyff, Rosemarie H., Kuchroo, Vijay, Zheng, Xin Xiao, Strom, Terry B.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2008
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2129234/
https://ncbi.nlm.nih.gov/pubmed/18079964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32562
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