Role of PSIP1/LEDGF/p75 in Lentiviral Infectivity and Integration Targeting

BACKGROUND: To replicate, lentiviruses such as HIV must integrate DNA copies of their RNA genomes into host cell chromosomes. Lentiviral integration is favored in active transcription units, which allows efficient viral gene expression after integration, but the mechanisms directing integration targ...

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Hlavní autoři: Marshall, Heather M., Ronen, Keshet, Berry, Charles, Llano, Manuel, Sutherland, Heidi, Saenz, Dyana, Bickmore, Wendy, Poeschla, Eric, Bushman, Frederic D.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2007
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2129110/
https://ncbi.nlm.nih.gov/pubmed/18092005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0001340
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