Role of PSIP1/LEDGF/p75 in Lentiviral Infectivity and Integration Targeting

BACKGROUND: To replicate, lentiviruses such as HIV must integrate DNA copies of their RNA genomes into host cell chromosomes. Lentiviral integration is favored in active transcription units, which allows efficient viral gene expression after integration, but the mechanisms directing integration targ...

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Detalhes bibliográficos
Main Authors: Marshall, Heather M., Ronen, Keshet, Berry, Charles, Llano, Manuel, Sutherland, Heidi, Saenz, Dyana, Bickmore, Wendy, Poeschla, Eric, Bushman, Frederic D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2129110/
https://ncbi.nlm.nih.gov/pubmed/18092005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0001340
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