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Activation of heteromeric G protein-gated inward rectifier K(+) channels overexpressed by adenovirus gene transfer inhibits the excitability of hippocampal neurons

G protein-gated inward rectifier K(+) channel subunits 1–4 (GIRK1–4) have been cloned from neuronal and atrial tissue and function as heterotetramers. To examine the inhibition of neuronal excitation by GIRKs, we overexpressed GIRKs in cultured hippocampal neurons from 18 day rat embryos, which norm...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Ehrengruber, Markus U., Doupnik, Craig A., Xu, Youfeng, Garvey, Justine, Jasek, Mark C., Lester, Henry A., Davidson, Norman
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1997
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21286/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9192693/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.13.7070
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