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Activation of heteromeric G protein-gated inward rectifier K(+) channels overexpressed by adenovirus gene transfer inhibits the excitability of hippocampal neurons

G protein-gated inward rectifier K(+) channel subunits 1–4 (GIRK1–4) have been cloned from neuronal and atrial tissue and function as heterotetramers. To examine the inhibition of neuronal excitation by GIRKs, we overexpressed GIRKs in cultured hippocampal neurons from 18 day rat embryos, which norm...

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Bibliografiske detaljer
Main Authors: Ehrengruber, Markus U., Doupnik, Craig A., Xu, Youfeng, Garvey, Justine, Jasek, Mark C., Lester, Henry A., Davidson, Norman
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences of the USA 1997
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC21286/
https://ncbi.nlm.nih.gov/pubmed/9192693
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