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Promoter choice affects the potency of HIV-1 specific RNA interference

RNA interference (RNAi) is mediated by small interfering (si) RNAs that target and degrade mRNA in a sequence-specific manner. Cellular expression of siRNA can be achieved by the use of expression cassettes driven by RNA polymerase III (pol III) promoters. Here, we demonstrate that a modified tRNA(m...

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Detalles Bibliográficos
Main Authors: Boden, Daniel, Pusch, Oliver, Lee, Fredrick, Tucker, Lynne, Shank, Peter R., Ramratnam, Bharat
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2003
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC212804/
https://ncbi.nlm.nih.gov/pubmed/12930953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkg704
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