SCF(β-TrCP) ubiquitin ligase-mediated processing of NF-κB p105 requires phosphorylation of its C-terminus by IκB kinase

Processing of the p105 precursor to form the active subunit p50 of the NF-κB transcription factor is a unique case in which the ubiquitin system is involved in limited processing rather than in complete destruction of the target substrate. A glycine-rich region along with a downstream acidic domain...

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Hoofdauteurs: Orian, Amir, Gonen, Hedva, Bercovich, Beatrice, Fajerman, Ifat, Eytan, Esther, Israël, Alain, Mercurio, Frank, Iwai, Kazuhiro, Schwartz, Alan L., Ciechanover, Aaron
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2000
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC212749/
https://ncbi.nlm.nih.gov/pubmed/10835356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.11.2580
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