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The conserved phosphoinositide 3-kinase pathway determines heart size in mice

Phosphoinositide 3-kinase (PI3K) has been shown to regulate cell and organ size in Drosophila, but the role of PI3K in vertebrates in vivo is not well understood. To examine the role of PI3K in intact mammalian tissue, we have created and characterized transgenic mice expressing constitutively activ...

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Détails bibliographiques
Auteurs principaux: Shioi, Tetsuo, Kang, Peter M., Douglas, Pamela S., Hampe, James, Yballe, Claudine M., Lawitts, Joel, Cantley, Lewis C., Izumo, Seigo
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2000
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC212739/
https://ncbi.nlm.nih.gov/pubmed/10835352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.11.2537
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