Overexpression of the human MNB/DYRK1A gene induces formation of multinucleate cells through overduplication of the centrosome

BACKGROUND: Previously we cloned the human MNB/DYRK1A gene from the "Down syndrome critical region" on chromosome 21. This gene encodes a dual specificity protein kinase that catalyzes its autophosphorylation on serine/threonine and tyrosine residues. But, the functions of the MNB/DYRK1A g...

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Main Authors: Funakoshi, Eishi, Hori, Takamitsu, Haraguchi, Tokuko, Hiraoka, Yasushi, Kudoh, Jun, Shimizu, Nobuyoshi, Ito, Fumiaki
格式: Artigo
語言:Inglês
出版: BioMed Central 2003
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC212362/
https://ncbi.nlm.nih.gov/pubmed/12964950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2121-4-12
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