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Down-regulation of DNA polymerase β accompanies somatic hypermutation in human BL2 cell lines
Somatic hypermutation (SHM) is a fundamental process in immunoglobulin gene maturation that results in increased affinity of antibodies toward antigens. In one hypothesis explaining SHM in human B cells, the process is initiated by enzymatic deamination of cytosine to uracil in the immunoglobulin ge...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2121660/ https://ncbi.nlm.nih.gov/pubmed/17127106 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2006.10.003 |
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