Cytotoxicity and mutagenicity of dibenzo[a,l]pyrene and (±)-dibenzo[a,l]pyrene-11,12-dihydrodiol in V79MZ cells co-expressing either hCYP1A1 or hCYP1B1 together with human glutathione-S-transferase A1

We have used V79MZ hamster lung fibroblasts stably transfected with human cytochrome P450-1A1 (hCYP1A1; cell line designated V79MZh1A1) or P450-1B1 (hCYP1B1; cell line designated V79MZh1B1) alone, or in combination with human GST alpha-1 (hGSTA1), in order to examine GST protection against cytotoxic...

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Detalhes bibliográficos
Main Authors: Kushman, Mary E., Kabler, Sandra L., Ahmad, Sarfaraz, Doehmer, Johannes, Morrow, Charles S., Townsend, Alan J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2121614/
https://ncbi.nlm.nih.gov/pubmed/17509623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrfmmm.2007.04.004
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