Cytotoxicity and mutagenicity of 5-methylchrysene and its 1,2-dihydrodiol in V79MZ cells modified to express human CYP1A1 or CYP1B1, in the presence or absence of human GSTP1 coexpression

The environmental carcinogen 5-methylchrysene (5MC) can be activated to mutagenic metabolites by several isozymes of cytochrome P450 (CYP). The resulting reactive diol-epoxides can be detoxified via conjugation by glutathione transferases (GST). We investigated whether expression of human glutathion...

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Main Authors: Ahmad, Sarfaraz, Kabler, Sandra L., Rudd, Lisa, Amin, Shantu, Doehmer, Johannes, Morrow, Charles S., Townsend, Alan J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2661874/
https://ncbi.nlm.nih.gov/pubmed/18992797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxlet.2008.10.008
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