Ligand-independent activation of platelet-derived growth factor receptor is a necessary intermediate in lysophosphatidic, acid-stimulated mitogenic activity in L cells

Growth factor-derived mitogenic signals from the cell surface are transmitted to the nucleus via receptor tyrosine kinases (RTKs), the adaptor proteins Shc and Grb2, and a Ras-dependent protein kinase cascade that activates the extracellular signal regulated kinase (ERK) subfamily of mitogen-activat...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Herrlich, Andreas, Daub, Henrik, Knebel, Axel, Herrlich, Peter, Ullrich, Axel, Schultz, Günter, Gudermann, Thomas
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1998
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21189/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9671791/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.15.8985
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