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Ligand-independent activation of platelet-derived growth factor receptor is a necessary intermediate in lysophosphatidic, acid-stimulated mitogenic activity in L cells

Growth factor-derived mitogenic signals from the cell surface are transmitted to the nucleus via receptor tyrosine kinases (RTKs), the adaptor proteins Shc and Grb2, and a Ras-dependent protein kinase cascade that activates the extracellular signal regulated kinase (ERK) subfamily of mitogen-activat...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Herrlich, Andreas, Daub, Henrik, Knebel, Axel, Herrlich, Peter, Ullrich, Axel, Schultz, Günter, Gudermann, Thomas
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 1998
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On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21189/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9671791/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.15.8985
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