Unregulated actin polymerization by WASp causes defects of mitosis and cytokinesis in X-linked neutropenia

Specific mutations in the human gene encoding the Wiskott-Aldrich syndrome protein (WASp) that compromise normal auto-inhibition of WASp result in unregulated activation of the actin-related protein 2/3 complex and increased actin polymerizing activity. These activating mutations are associated with...

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Detaylı Bibliyografya
Asıl Yazarlar: Moulding, Dale A., Blundell, Michael P., Spiller, David G., White, Michael R.H., Cory, Giles O., Calle, Yolanda, Kempski, Helena, Sinclair, Jo, Ancliff, Phil J., Kinnon, Christine, Jones, Gareth E., Thrasher, Adrian J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Rockefeller University Press 2007
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Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118706/
https://ncbi.nlm.nih.gov/pubmed/17724125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20062324
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