Unregulated actin polymerization by WASp causes defects of mitosis and cytokinesis in X-linked neutropenia

Specific mutations in the human gene encoding the Wiskott-Aldrich syndrome protein (WASp) that compromise normal auto-inhibition of WASp result in unregulated activation of the actin-related protein 2/3 complex and increased actin polymerizing activity. These activating mutations are associated with...

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Main Authors: Moulding, Dale A., Blundell, Michael P., Spiller, David G., White, Michael R.H., Cory, Giles O., Calle, Yolanda, Kempski, Helena, Sinclair, Jo, Ancliff, Phil J., Kinnon, Christine, Jones, Gareth E., Thrasher, Adrian J.
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2007
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118706/
https://ncbi.nlm.nih.gov/pubmed/17724125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20062324
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