Unregulated actin polymerization by WASp causes defects of mitosis and cytokinesis in X-linked neutropenia

Specific mutations in the human gene encoding the Wiskott-Aldrich syndrome protein (WASp) that compromise normal auto-inhibition of WASp result in unregulated activation of the actin-related protein 2/3 complex and increased actin polymerizing activity. These activating mutations are associated with...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Moulding, Dale A., Blundell, Michael P., Spiller, David G., White, Michael R.H., Cory, Giles O., Calle, Yolanda, Kempski, Helena, Sinclair, Jo, Ancliff, Phil J., Kinnon, Christine, Jones, Gareth E., Thrasher, Adrian J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Rockefeller University Press 2007
Pynciau:
Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118706/
https://ncbi.nlm.nih.gov/pubmed/17724125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20062324
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