MK2 controls the level of negative feedback in the NF-κB pathway and is essential for vascular permeability and airway inflammation

We demonstrate that mitogen-activated protein kinase–activated kinase-2 (MK2) is essential for localized Th2-type inflammation and development of experimental asthma. MK2 deficiency does not affect systemic Th2 immunity, but reduces endothelial permeability, as well as adhesion molecule and chemokin...

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Main Authors:	Gorska, Magdalena M., Liang, Qiaoling, Stafford, Susan J., Goplen, Nicolas, Dharajiya, Nilesh, Guo, Lei, Sur, Sanjiv, Gaestel, Matthias, Alam, Rafeul
Format:	Artigo
Sprog:	Inglês
Udgivet:	The Rockefeller University Press 2007
Fag:	Articles
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2118652/ https://ncbi.nlm.nih.gov/pubmed/17576778 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20062621
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MK2 controls the level of negative feedback in the NF-κB pathway and is essential for vascular permeability and airway inflammation

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