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MK2 controls the level of negative feedback in the NF-κB pathway and is essential for vascular permeability and airway inflammation
We demonstrate that mitogen-activated protein kinase–activated kinase-2 (MK2) is essential for localized Th2-type inflammation and development of experimental asthma. MK2 deficiency does not affect systemic Th2 immunity, but reduces endothelial permeability, as well as adhesion molecule and chemokin...
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| Главные авторы: | , , , , , , , , |
|---|---|
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The Rockefeller University Press
2007
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2118652/ https://ncbi.nlm.nih.gov/pubmed/17576778 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20062621 |
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