A critical role for IRAK4 kinase activity in Toll-like receptor–mediated innate immunity

IRAK4 is a member of IL-1 receptor (IL-1R)–associated kinase (IRAK) family and has been shown to play an essential role in Toll-like receptor (TLR)–mediated signaling. We recently generated IRAK4 kinase-inactive knock-in mice to examine the role of kinase activity of IRAK4 in TLR-mediated signaling...

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Hlavní autoři: Kim, Tae Whan, Staschke, Kirk, Bulek, Katarzyna, Yao, Jianhong, Peters, Kristi, Oh, Keun-Hee, Vandenburg, Yvonne, Xiao, Hui, Qian, Wen, Hamilton, Tom, Min, Booki, Sen, Ganes, Gilmour, Raymond, Li, Xiaoxia
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2007
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118590/
https://ncbi.nlm.nih.gov/pubmed/17470642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20061825
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