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The dual functions of IRAK2 in TLR9–mediated interferon and proinflammatory cytokine production
Bone marrow-derived plasmacytoid dendritic cells (pDCs) from IRAK2-deficient mice produced more interferons than did wild-type pDCs upon stimulation with the TLR9 ligand CpG. Furthermore, in CpG-stimulated IRAK2-deficient pDCs there was increased nuclear translocation of interferon regulatory factor...
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| Главные авторы: | , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3163905/ https://ncbi.nlm.nih.gov/pubmed/21270393 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1003217 |
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