IRAK4 kinase Activity is Required for Th17 Differentiation and Th17-mediated Disease

Both IL-23- and IL-1-mediated signaling pathways play important roles in Th17 cell differentiation, cytokine production, and autoimmune diseases. The IL-1 receptor associated kinase 4 (IRAK4) is critical for IL-1/TLR signaling. We show here that inactivation of IRAK4 kinase in mice (IRAK4 KI) result...

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Hauptverfasser: Staschke, Kirk A., Dong, Sucai, Saha, Joy, Zhao, Jingyong, Brooks, Nathan A., Hepburn, Deena L., Xia, Jinqi, Gulen, Muhammet F., Kang, Zizhen, Altuntas, Cengiz Z., Tuohy, Vincent K., Gilmour, Raymond, Li, Xiaoxia, Na, Songqing
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3638260/
https://ncbi.nlm.nih.gov/pubmed/19542468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0802361
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