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Fetal gene defects precipitate platelet-mediated pregnancy failure in factor V Leiden mothers
We describe a mouse model of fetal loss in factor V Leiden (FvL) mothers in which fetal loss is triggered when the maternal prothrombotic state coincides with fetal gene defects that reduce activation of the protein C anticoagulant pathway within the placenta. Fetal loss is caused by disruption of p...
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| Autors principals: | , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The Rockefeller University Press
2007
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2118565/ https://ncbi.nlm.nih.gov/pubmed/17438064 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20062566 |
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