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Complement activation induces dysregulation of angiogenic factors and causes fetal rejection and growth restriction

Immune mechanisms have been implicated in placental dysfunction in patients with recurrent miscarriages and intrauterine growth restriction (IUGR), but the mediators are undefined. Here we show that complement activation, particularly C5a, is a required intermediary event in the pathogenesis of plac...

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Bibliographic Details
Main Authors: Girardi, Guillermina, Yarilin, Dmitry, Thurman, Joshua M., Holers, V. Michael, Salmon, Jane E.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2006
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118387/
https://ncbi.nlm.nih.gov/pubmed/16923853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20061022
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