Fetal gene defects precipitate platelet-mediated pregnancy failure in factor V Leiden mothers

We describe a mouse model of fetal loss in factor V Leiden (FvL) mothers in which fetal loss is triggered when the maternal prothrombotic state coincides with fetal gene defects that reduce activation of the protein C anticoagulant pathway within the placenta. Fetal loss is caused by disruption of p...

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Bibliographic Details
Main Authors: Sood, Rashmi, Zogg, Mark, Westrick, Randal J., Guo, Yi-he, Kerschen, Edward J., Girardi, Guillermina, Salmon, Jane E., Coughlin, Shaun R., Weiler, Hartmut
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2007
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118565/
https://ncbi.nlm.nih.gov/pubmed/17438064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20062566
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