Jinx, an MCMV susceptibility phenotype caused by disruption of Unc13d: a mouse model of type 3 familial hemophagocytic lymphohistiocytosis

Mouse cytomegalovirus (MCMV) susceptibility often results from defects of natural killer (NK) cell function. Here we describe Jinx, an N-ethyl-N-nitrosourea–induced MCMV susceptibility mutation that permits unchecked proliferation of the virus, causing death. In Jinx homozygotes, activated NK cells...

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Detalhes bibliográficos
Main Authors: Crozat, Karine, Hoebe, Kasper, Ugolini, Sophie, Hong, Nancy A., Janssen, Edith, Rutschmann, Sophie, Mudd, Suzanne, Sovath, Sosathya, Vivier, Eric, Beutler, Bruce
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2007
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118559/
https://ncbi.nlm.nih.gov/pubmed/17420270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20062447
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