HMGB1 release induced by liver ischemia involves Toll-like receptor 4–dependent reactive oxygen species production and calcium-mediated signaling

Ischemic tissues require mechanisms to alert the immune system of impending cell damage. The nuclear protein high-mobility group box 1 (HMGB1) can activate inflammatory pathways when released from ischemic cells. We elucidate the mechanism by which HMGB1, one of the key alarm molecules released duri...

Full description

Saved in:
Bibliographic Details
Main Authors: Tsung, Allan, Klune, John R., Zhang, Xianghong, Jeyabalan, Geetha, Cao, Zongxian, Peng, Ximei, Stolz, Donna B., Geller, David A., Rosengart, Matthew R., Billiar, Timothy R.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2007
Subjects:
Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118528/
https://ncbi.nlm.nih.gov/pubmed/17984303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20070247
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items