ARGINASE BLOCKADE PROTECTS AGAINST HEPATIC DAMAGE IN WARM ISCHEMIA-REPERFUSION

BACKGROUND: Liver ischemia reperfusion (I/R) injury is associated with profound arginine depletion due to arginase release from injured hepatocytes. Nitric oxide (NO), shown to have protective effects in I/R, is produced by nitric oxide synthase (NOS) from the substrate arginine. The purpose of this...

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Detalhes bibliográficos
Main Authors: Jeyabalan, Geetha, Klune, John R., Nakao, Atsunori, Martik, Nicole, Wu, Guoyao, Tsung, Allan, Geller, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2527546/
https://ncbi.nlm.nih.gov/pubmed/18456004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.niox.2008.04.002
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