HMGB1 release induced by liver ischemia involves Toll-like receptor 4–dependent reactive oxygen species production and calcium-mediated signaling

Ischemic tissues require mechanisms to alert the immune system of impending cell damage. The nuclear protein high-mobility group box 1 (HMGB1) can activate inflammatory pathways when released from ischemic cells. We elucidate the mechanism by which HMGB1, one of the key alarm molecules released duri...

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Hauptverfasser: Tsung, Allan, Klune, John R., Zhang, Xianghong, Jeyabalan, Geetha, Cao, Zongxian, Peng, Ximei, Stolz, Donna B., Geller, David A., Rosengart, Matthew R., Billiar, Timothy R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2007
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118528/
https://ncbi.nlm.nih.gov/pubmed/17984303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20070247
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