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SAP regulates T cell–mediated help for humoral immunity by a mechanism distinct from cytokine regulation
X-linked lymphoproliferative disease is caused by mutations affecting SH2D1A/SAP, an adaptor that recruits Fyn to signal lymphocyte activation molecule (SLAM)-related receptors. After infection, SLAM-associated protein (SAP)(−/−) mice show increased T cell activation and impaired humoral responses....
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2118305/ https://ncbi.nlm.nih.gov/pubmed/16754717 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20052097 |
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