SAP regulates T cell–mediated help for humoral immunity by a mechanism distinct from cytokine regulation

X-linked lymphoproliferative disease is caused by mutations affecting SH2D1A/SAP, an adaptor that recruits Fyn to signal lymphocyte activation molecule (SLAM)-related receptors. After infection, SLAM-associated protein (SAP)(−/−) mice show increased T cell activation and impaired humoral responses....

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Cannons, Jennifer L., Yu, Li J., Jankovic, Dragana, Crotty, Shane, Horai, Reiko, Kirby, Martha, Anderson, Stacie, Cheever, Allen W., Sher, Alan, Schwartzberg, Pamela L.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2006
Fag:
Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118305/
https://ncbi.nlm.nih.gov/pubmed/16754717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20052097
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker