Block of C/EBPα function by phosphorylation in acute myeloid leukemia with FLT3 activating mutations

Mutations constitutively activating FLT3 kinase are detected in ∼30% of acute myelogenous leukemia (AML) patients and affect downstream pathways such as extracellular signal–regulated kinase (ERK)1/2. We found that activation of FLT3 in human AML inhibits CCAAT/enhancer binding protein α (C/EBPα) fu...

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Hlavní autoři: Radomska, Hanna S., Bassères, Daniela S., Zheng, Rui, Zhang, Pu, Dayaram, Tajhal, Yamamoto, Yukiya, Sternberg, David W., Lokker, Nathalie, Giese, Neill A., Bohlander, Stefan K., Schnittger, Susanne, Delmotte, Marie-Hélène, Davis, Roger J., Small, Donald, Hiddemann, Wolfgang, Gilliland, D. Gary, Tenen, Daniel G.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2006
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Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118199/
https://ncbi.nlm.nih.gov/pubmed/16446383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20052242
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