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Role of mitochondrial glucocorticoid receptor in glucocorticoid-induced apoptosis

The mechanisms by which glucocorticoid receptor (GR) mediates glucocorticoid (GC)-induced apoptosis are unknown. We studied the role of mitochondrial GR in this process. Dexamethasone induces GR translocation to the mitochondria in GC-sensitive, but not in GC-resistant, T cell lines. In contrast, nu...

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Détails bibliographiques
Auteurs principaux: Sionov, Ronit Vogt, Cohen, Orly, Kfir, Shlomit, Zilberman, Yael, Yefenof, Eitan
Format: Artigo
Langue:Inglês
Publié: The Rockefeller University Press 2006
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118093/
https://ncbi.nlm.nih.gov/pubmed/16390935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20050433
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