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A Role for Bcl-2 in Notch1-Dependent Transcription in Thymic Lymphoma Cells

Notch1 is a transcription factor important for T-cell development. Notch1 is active in double negative (DN) thymocytes, while being depressed in double positive (DP) thymocytes. Synchronously, the expression of Bcl-2 becomes downregulated during the transition from DN to DP thymocytes. We previously...

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Autors principals: Sionov, Ronit Vogt, Kfir-Erenfeld, Shlomit, Spokoini, Rachel, Yefenof, Eitan
Format: Artigo
Idioma:Inglês
Publicat: Hindawi Publishing Corporation 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3272787/
https://ncbi.nlm.nih.gov/pubmed/22319533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/435241
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