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SR-BI protects against endotoxemia in mice through its roles in glucocorticoid production and hepatic clearance
Septic shock results from an uncontrolled inflammatory response, mediated primarily by LPS. Cholesterol transport plays an important role in the host response to LPS, as LPS is neutralized by lipoproteins and adrenal cholesterol uptake is required for antiinflammatory glucocorticoid synthesis. In th...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Clinical Investigation
2007
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2117761/ https://ncbi.nlm.nih.gov/pubmed/18064300 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI31539 |
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