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A phage display approach for rapid antibody humanization: Designed combinatorial V gene libraries

The development of a new strategy for antibody humanization is described. This strategy incorporates key recognition sequences from the parental rodent antibody into a phage display-based selection strategy. The original sequences of the third complementarity-determining regions (CDRs) of heavy and...

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Bibliografiske detaljer
Main Authors: Rader, Christoph, Cheresh, David A., Barbas, Carlos F.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 1998
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC21176/
https://ncbi.nlm.nih.gov/pubmed/9671778
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