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Evidence for gene silencing by endogenous DNA methylation

Transformed cells can spontaneously silence genes by de novo methylation, and it is generally assumed that this is due to DNA methyltransferase activity. We have tested the alternative hypothesis that gene silencing could be due to the uptake of 5-methyl-dCMP into DNA, via the di- and triphosphonucl...

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Sonraí Bibleagrafaíochta
Main Authors: Holliday, Robin, Ho, Thu
Formáid: Artigo
Teanga:Inglês
Foilsithe: The National Academy of Sciences 1998
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC21144/
https://ncbi.nlm.nih.gov/pubmed/9671746
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