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Evidence for gene silencing by endogenous DNA methylation

Transformed cells can spontaneously silence genes by de novo methylation, and it is generally assumed that this is due to DNA methyltransferase activity. We have tested the alternative hypothesis that gene silencing could be due to the uptake of 5-methyl-dCMP into DNA, via the di- and triphosphonucl...

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Bibliografische gegevens
Hoofdauteurs: Holliday, Robin, Ho, Thu
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The National Academy of Sciences 1998
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC21144/
https://ncbi.nlm.nih.gov/pubmed/9671746
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