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Evidence for gene silencing by endogenous DNA methylation

Transformed cells can spontaneously silence genes by de novo methylation, and it is generally assumed that this is due to DNA methyltransferase activity. We have tested the alternative hypothesis that gene silencing could be due to the uptake of 5-methyl-dCMP into DNA, via the di- and triphosphonucl...

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Bibliografski detalji
Glavni autori: Holliday, Robin, Ho, Thu
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 1998
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC21144/
https://ncbi.nlm.nih.gov/pubmed/9671746
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