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Dormant origins licensed by excess Mcm2–7 are required for human cells to survive replicative stress
In late mitosis and early G1, Mcm2–7 complexes are loaded onto DNA to license replication origins for use in the upcoming S phase. However, the amount of Mcm2–7 loaded is in significant excess over the number of origins normally used. We show here that in human cells, excess chromatin-bound Mcm2–7 l...
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| Päätekijät: | , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Cold Spring Harbor Laboratory Press
2007
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2113033/ https://ncbi.nlm.nih.gov/pubmed/18079179 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.457807 |
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