Induction of Tau Pathology by Intracerebral Infusion of Amyloid-β-Containing Brain Extract and by Amyloid-β Deposition in APP × Tau Transgenic Mice

Alzheimer’s disease presents morphologically with senile plaques, primarily made of extracellular amyloid-β (Aβ) deposits, and neurofibrillary lesions, which consist of intracellular aggregates of hyperphosphorylated tau protein. To study the in vivo induction of tau pathology, dilute brain extracts...

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Bibliographische Detailangaben
Hauptverfasser: Bolmont, Tristan, Clavaguera, Florence, Meyer-Luehmann, Melanie, Herzig, Martin C., Radde, Rebecca, Staufenbiel, Matthias, Lewis, Jada, Hutton, Mike, Tolnay, Markus, Jucker, Mathias
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Investigative Pathology 2007
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Regular Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2111123/
https://ncbi.nlm.nih.gov/pubmed/18055549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2007.070403
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