Engineering subunit association of multisubunit proteins: A dimeric streptavidin

A dimeric streptavidin has been designed by molecular modeling using effective binding free energy calculations that decompose the binding free energy into electrostatic, desolvation, and side chain entropy loss terms. A histidine-127 → aspartic acid (H127D) mutation was sufficient to introduce elec...

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Bibliografiska uppgifter
Huvudupphovsmän: Sano, Takeshi, Vajda, Sandor, Smith, Cassandra L., Cantor, Charles R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The National Academy of Sciences of the USA 1997
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC21018/
https://ncbi.nlm.nih.gov/pubmed/9177186
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