A streptavidin mutant with altered ligand-binding specificity
The biotin-binding site of streptavidin was modified to alter its ligand-binding specificity. In natural streptavidin, the side chains of N23 and S27 make two of the three hydrogen bonds with the ureido oxygen of biotin. These two residues were mutated to severely weaken biotin binding while attempt...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1998
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24852/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9811833/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.23.13525 |
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