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The Beyond 12/23 Restriction Is Imposed at the Nicking and Pairing Steps of DNA Cleavage during V(D)J Recombination

The beyond 12/23 (B12/23) rule ensures inclusion of a Dβ gene segment in the assembled T-cell receptor (TCR) β variable region exon and is manifest by a failure of direct Vβ-to-Jβ gene segment joining. The restriction is enforced during the DNA cleavage step of V(D)J recombination by the recombinati...

詳細記述

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書誌詳細
主要な著者: Drejer-Teel, Anna H., Fugmann, Sebastian D., Schatz, David G.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology (ASM) 2007
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2099602/
https://ncbi.nlm.nih.gov/pubmed/17636023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00835-07
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