Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding

Neuropilins (Nrps) are co-receptors for class 3 semaphorins and vascular endothelial growth factors and important for the development of the nervous system and the vasculature. The extracellular portion of Nrp is composed of two domains that are essential for semaphorin binding (a1a2), two domains n...

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Main Authors: Appleton, Brent A, Wu, Ping, Maloney, Janice, Yin, JianPing, Liang, Wei-Ching, Stawicki, Scott, Mortara, Kyle, Bowman, Krista K, Elliott, J Michael, Desmarais, William, Bazan, J Fernando, Bagri, Anil, Tessier-Lavigne, Marc, Koch, Alexander W, Wu, Yan, Watts, Ryan J, Wiesmann, Christian
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2007
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2099469/
https://ncbi.nlm.nih.gov/pubmed/17989695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601906
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