Floor plate-derived neuropilin-2 functions as a secreted semaphorin sink to facilitate commissural axon midline crossing

Commissural axon guidance depends on a myriad of cues expressed by intermediate targets. Secreted semaphorins signal through neuropilin-2/plexin-A1 receptor complexes on post-crossing commissural axons to mediate floor plate repulsion in the mouse spinal cord. Here, we show that neuropilin-2/plexin-...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Hernandez-Enriquez, Berenice, Wu, Zhuhao, Martinez, Edward, Olsen, Olav, Kaprielian, Zaven, Maness, Patricia F., Yoshida, Yutaka, Tessier-Lavigne, Marc, Tran, Tracy S.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4699389/
https://ncbi.nlm.nih.gov/pubmed/26680304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.268086.115
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