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Erlotinib Effectively Inhibits JAK2(V617F) Activity and Polycythemia Vera Cell Growth
JAK2(V617F), a mutant of tyrosine kinase JAK2, is found in most patients with polycythemia vera (PV) and a substantial proportion of patients with idiopathic myelofibrosis or essential thrombocythemia. The JAK2 mutant displays a much increased kinase activity and generates a PV-like phenotype in mou...
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| Autores principales: | , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2006
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2096634/ https://ncbi.nlm.nih.gov/pubmed/17178722 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C600277200 |
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