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Mutations in α-Tubulin Confer Dinitroaniline Resistance at a Cost to Microtubule Function

Protozoan microtubules are sensitive to disruption by dinitroanilines, compounds that kill intracellular Toxoplasma gondii parasites without affecting microtubules in vertebrate host cells. We previously isolated a number of resistant Toxoplasma lines that harbor mutations to the α1-tubulin gene. So...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Ma, Christopher, Li, Catherine, Ganesan, Lakshmi, Oak, Jean, Tsai, Susan, Sept, David, Morrissette, Naomi S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Cell Biology 2007
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2096588/
https://ncbi.nlm.nih.gov/pubmed/17881728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E07-04-0379
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